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Propranolol is metabolized through three primary routes: aromatic hydroxylation (mainly 4-hydroxylation), N-dealkylation followed by further side-chain oxidation, and direct glucuronidation.
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To this solution, 4-N,N-dimethylamino-3-pyridinyl-boronic acid (248 mg, 1.5 mmol, dissolved in 10 mL of DMF) was added and the reaction mixture was heated for another 2 hours.
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